Endocrine Abstracts

Objective: Thyroid autoimmunity has been proposed as a risk factor for impaired health-related Quality of Life (HRQoL), depression and anxiety, though evidence is still limited. The aim of the current study is to assess the association of thyroid autoimmunity with quality of life in patients with benign thyroid disease.Design: A cross-sectional study was implemented, that included consecutive patients with benign thyroid diseases who visited the outpatie...

Milk – alkali syndrome is a rare and distinctive disorder caused by ingestion of large amounts of calcium and absorbable alkali resulting in hypercalcemia. It is characterized by a triad of hypercalcemia, metabolic alkalosis and renal failure. Here we present a 59 years old female patient, who presented to Emergency department for a fall and Syncopal episode. She had a few days history of increasing thirst, polyuria and diffuse abdominal discomfort. This prior to her sync...

Introduction: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) represents a rare but rather more aggressive subtype of PTC.Purpose: Description of a patient with DSPC and background autoimmune thyroiditis.Case description: A 33-year-old female patient reported extensive neck swelling that had progressed over several months. The patient had been diagnosed with hypothyroidism attributed to autoimmune thyroiditis, 3 ye...

Introduction: PD-1 inhibitors are powerful disruptors of self- tolerance and autoimmune diabetes develops in up to 0.9% of patients. Lipodystrophic insulin reactions, although uncommon with human insulin analogs, are a recognized cause of impaired insulin delivery in patients on intensive insulin regimens. We describe a patient with resistant lymphoma and nivolumab-induced autoimmune diabetes, who suffered loss of glycemic control due to early radiation-induced subcutaneous fi...

Introduction: Patients with benign thyroid disease may present an impaired Quality of Life (QoL). However, evidence of cosmetic complaints in patients with thyroid disease is limited. The aim of the current study was to investigate the cosmetic complaints of patients with thyroid disease and determine any associations with specific clinical characteristics.Methods: A cross-sectional study was performed. Patients with benign thyroid disease who attended t...

Introduction: Subclinical hypercortisolism (SH) has been reported in 5–20% of patients with adrenal incidentalomas (AIs), with various cardiometabolic consequences. We intended to investigate the contribution of DHEAS to standard testing, as another indicator of autonomous cortisol secretion in AIs.Materials and methods: Ninety consecutive patients (n=90) with AIs were included in a prospective cohort study. SH was diagnosed if ≥2 cri...

Introduction: Thyroid autoimmunity has been associated with the diagnosis of differentiated thyroid (DTC) cancer in surgical series. However, this finding has not been consistent in Fine Needle Aspiration Biopsy (FNAB) cytology series.Aim: We aimed to investigate the association between thyroid autoimmunity and DTC in patients who underwent ultrasound-guided FNAB.Methods: A retrospective analysis of patients who had undergone ultra...

Introduction: Thyroid sonography has become the first line diagnostic procedure for thyroid nodules. The characterization of specific sonografic patterns associated with high risk of malignancy has enabled physicians to determine which nodules are more likely to be malignant and thus merit further evaluation.Aim: We investigated whether the ultrasonographic nodule characteristics proposed in the literature were able to predict cytology findings after ult...

Background: Lymph node metastasis from papillary thyroid cancer without detectable primary within the thyroid gland is extremely rare. We describe a case of a young woman with a cervical metastasis, without detectable orthotopic or ectopic thyroid focus.Case report: A 30-year old woman with a history of adenocarcinoma of the ascending colon six years previously, presented at the 15th week of a normal second pregnancy, for management of subclinical Hashim...

Introduction: Adrenal Incidentalomas (AIs) have been associated with an increased risk of metabolic syndrome and dyslipidemia, though evidence regarding the latter is limited and, sometimes conflicting. Lipid abnormalities in patients with AIs have been described to be associated with subclinical hypercortisolism. Our aim was to test if lipid profile in patients with adrenal incidentalomas may predict subclinical Cushing’s Syndrome (sCS).Material an...